Clinical Characteristics and Predictors of Mortality in Critically Ill Adult Patients with Influenza Infection.
Int J Environ Res Public Health
; 18(7)2021 04 01.
Article
em En
| MEDLINE
| ID: mdl-33916073
ABSTRACT
Patients with influenza infection may develop acute respiratory distress syndrome (ARDS), which is associated with high mortality. Some patients with ARDS receiving extracorporeal membrane oxygenation (ECMO) support die of infectious complications. We aimed to investigate the risk factors affecting the clinical outcomes in critically ill patients with influenza. We retrospectively reviewed the medical records of influenza patients between January 2006 and May 2016 at the Kaohsiung Veterans General Hospital in Taiwan. Patients aged below 20 years or without laboratory-confirmed influenza were excluded. Critically ill patients who presented with ARDS (P = 0.004, odds ratio (OR) 8.054, 95% confidence interval (CI) 1.975-32.855), a higher Acute Physiology and Chronic Health Evaluation (APACHE) II score (P = 0.008, OR 1.102, 95% CI 1.025-1.184), or higher positive end-expiratory pressure (P = 0.008, OR 1.259, 95% CI 1.061-1.493) may have a higher risk of receiving ECMO. Influenza A (P = 0.037, OR 0.105, 95% CI 0.013-0.876) and multiple organ failure (P = 0.007, OR 0.056, 95% CI 0.007-0.457) were significantly associated with higher mortality rates. In conclusion, our study showed critically ill influenza patients with ARDS, higher APACHE II scores, and higher positive end-expiratory pressure have a higher risk of receiving ECMO support. Influenza A and multiple organ failure are predictors of mortality.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Desconforto Respiratório
/
Influenza Humana
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article