Convection Enhanced Delivery in the Setting of High-Grade Gliomas.

Nwagwu, Chibueze D; Immidisetti, Amanda V; Jiang, Michael Y; Adeagbo, Oluwasegun; Adamson, David C; Carbonell, Anne-Marie

Nwagwu, Chibueze D; Immidisetti, Amanda V; Jiang, Michael Y; Adeagbo, Oluwasegun; Adamson, David C; Carbonell, Anne-Marie.

Afiliação

Nwagwu CD; Emory University School of Medicine, Atlanta, GA 30322, USA.
Immidisetti AV; Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
Jiang MY; Imperial College School of Medicine, London SW7 2DD, UK.
Adeagbo O; Emory University School of Medicine, Atlanta, GA 30322, USA.
Adamson DC; Department of Neurosurgery, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Carbonell AM; Atlanta VA Healthcare System, Decatur, GA 30033, USA.

Pharmaceutics ; 13(4)2021 Apr 15.

Article em En | MEDLINE | ID: mdl-33921157

ABSTRACT

ABSTRACT

Development of effective treatments for high-grade glioma (HGG) is hampered by (1) the blood-brain barrier (BBB), (2) an infiltrative growth pattern, (3) rapid development of therapeutic resistance, and, in many cases, (4) dose-limiting toxicity due to systemic exposure. Convection-enhanced delivery (CED) has the potential to significantly limit systemic toxicity and increase therapeutic index by directly delivering homogenous drug concentrations to the site of disease. In this review, we present clinical experiences and preclinical developments of CED in the setting of high-grade gliomas.

Palavras-chave

clinical trials; convection enhanced delivery; direct delivery; glioblastoma; high-grade glioma; neuro-oncology; refractory glioblastoma; refractory glioma

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article