Mildronate protects heart mtDNA from oxidative stress toxicity induced by exhaustive physical exercise.
Arch Biochem Biophys
; 705: 108892, 2021 07 15.
Article
em En
| MEDLINE
| ID: mdl-33930377
ABSTRACT
Exhaustive physical exercises are potentially dangerous for human's physical health and may lead to chronic heart disease. Therefore, individuals involved in such activity require effective and safe cardioprotectors. The goal of this research was to study Mildronate (a cardioprotective drug) effect on the level of oxidative stress markers in hearts of mice under conditions of exhausting physical exercise, such as forced swimming for 1 h per day for 7 days. Forced swimming lead to mtDNA damage accumulation, increase in diene conjugates level and loss of reduced glutathione despite an increase in antioxidant genes expression and activation of mitochondrial biogenesis. Mildronate treatment reduced oxidative stress, probably due to the inhibition of fatty acids transport to mitochondria and an increase in the intensity of glucose oxidation, which in part confirms by increase in glucose transporter expression. Thus, we can assume that Mildronate is an effective cardioprotector in exhaustive physical exercises.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
/
DNA Mitocondrial
/
Estresse Oxidativo
/
Metilidrazinas
/
Mitocôndrias Cardíacas
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article