A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners.

Rezaei Adariani, Soheila; Kazemein Jasemi, Neda S; Bazgir, Farhad; Wittich, Christoph; Amin, Ehsan; Seidel, Claus A M; Dvorsky, Radovan; Ahmadian, Mohammad R

Rezaei Adariani, Soheila; Kazemein Jasemi, Neda S; Bazgir, Farhad; Wittich, Christoph; Amin, Ehsan; Seidel, Claus A M; Dvorsky, Radovan; Ahmadian, Mohammad R.

Afiliação

Rezaei Adariani S; Medical Faculty, Institute of Biochemistry and Molecular Biology II, Heinrich Heine University, Düsseldorf, Germany.
Kazemein Jasemi NS; Medical Faculty, Institute of Biochemistry and Molecular Biology II, Heinrich Heine University, Düsseldorf, Germany.
Bazgir F; Medical Faculty, Institute of Biochemistry and Molecular Biology II, Heinrich Heine University, Düsseldorf, Germany.
Wittich C; Medical Faculty, Institute of Biochemistry and Molecular Biology II, Heinrich Heine University, Düsseldorf, Germany.
Amin E; Medical Faculty, Institute of Biochemistry and Molecular Biology II, Heinrich Heine University, Düsseldorf, Germany; Medical Faculty, Institute of Neural and Sensory Physiology, Heinrich Heine University, Düsseldorf, Germany.
Seidel CAM; Chair of Molecular Physical Chemistry, Heinrich Heine University, Düsseldorf, Germany.
Dvorsky R; Medical Faculty, Institute of Biochemistry and Molecular Biology II, Heinrich Heine University, Düsseldorf, Germany.
Ahmadian MR; Medical Faculty, Institute of Biochemistry and Molecular Biology II, Heinrich Heine University, Düsseldorf, Germany. Electronic address: reza.ahmadian@hhu.de.

J Biol Chem ; 296: 100626, 2021.

Article em En | MEDLINE | ID: mdl-33930461

Assuntos

Proteínas Reguladoras de Apoptose/metabolismo; Domínios e Motivos de Interação entre Proteínas; Proteínas Supressoras de Tumor/metabolismo; Proteínas ras/metabolismo; Proteínas Reguladoras de Apoptose/genética; Biologia Computacional; Células HEK293; Humanos; Ligação Proteica; Transdução de Sinais; Proteínas Supressoras de Tumor/genética; Proteínas ras/genética

Palavras-chave

GTPase; NORE-1; RAS; RAS association domain; RAS-binding domain; RASSF; RASSF1; RASSF5; effectors; protein interactions

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas ras / Proteínas Supressoras de Tumor / Proteínas Reguladoras de Apoptose / Domínios e Motivos de Interação entre Proteínas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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