Infective endocarditis and outcomes of mitral valve replacement.
Eur J Clin Invest
; 51(9): e13577, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-33931874
ABSTRACT
BACKGROUND:
We investigated the long-term outcomes of mitral valve replacement (MVR) in native mitral valve infective endocarditis (IE).METHODS:
Multicentre, population-based cohort register study consisted of 1233 consecutive adult patients treated with first-time MVR in Finland. Mitral valve IE was diagnosed in 170 of these patients. Propensity score matching resulted in 134 pairs with balanced baseline characteristics. The median follow-up was 6.1 years.RESULTS:
Pre-operative native mitral valve IE was associated with an increased hazard of 10-year mortality (38.8% vs 30.5%; HR 2.13; CI 1.17-3.85; P = .013) after MVR. Occurrence of major bleeding was higher in IE patients (26.0%) vs non-IE patients (23.4%) during the 10-year follow-up (HR 2.80; CI 1.01-7.77; P = .048). Hospital admission duration after MVR was longer in IE patients (median 28 vs 11 days; P < .0001). Cumulative ischaemic stroke rate was similar between patient groups (12.1% in IE vs 15.1% in non-IE; P = .493). Re-sternotomy was performed in 13.4% of IE patients and 9.0% of non-IE patients (P = .261).CONCLUSIONS:
Patients with native mitral valve IE have a higher risk of death and major bleeding after MVR than matched patients without IE. Results highlight the importance of complication prevention in these patients.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Mortalidade
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Implante de Prótese de Valva Cardíaca
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Endocardite
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AVC Isquêmico
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Hemorragia
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Hospitalização
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Valva Mitral
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Insuficiência da Valva Mitral
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article