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Laryngeal function in normal dogs administered isoflurane following partial clearance of alfaxalone or propofol.
Kapaldo, Nathaniel; McMurphy, Rose; Hodgson, David; Roush, James; Berke, Kara; Klocke, Emily.
Afiliação
  • Kapaldo N; Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA. Electronic address: Kapaldo@vet.k-state.edu.
  • McMurphy R; Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
  • Hodgson D; Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
  • Roush J; Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
  • Berke K; Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
  • Klocke E; Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Vet Anaesth Analg ; 48(4): 493-500, 2021 Jul.
Article em En | MEDLINE | ID: mdl-33941487
OBJECTIVE: To assess laryngeal function in normal dogs administered isoflurane following partial clearance of alfaxalone or propofol. STUDY DESIGN: Randomized experimental crossover study. ANIMALS: A group of 12 purpose-bred, male Beagle dogs. METHODS: Dogs were randomly assigned to one of two treatments: alfaxalone-isoflurane (ALF-ISO) or propofol-isoflurane (PRO-ISO) and anesthetized for three video laryngoscopy examinations. The alternate treatment occurred after ≥ 14 days interval. Examinations were performed after induction of anesthesia (LS-A), after 20 minutes of breathing isoflurane via a facemask (LS-B) and after a further 20 minutes of isoflurane (LS-C). Parameters of objective laryngeal function included inspiratory rima glottidis surface area (RGSA-I), expiratory rima glottidis surface area (RGSA-E) and % RGSA increase, calculated from three consecutive respiratory cycles in the final 15 seconds of each video laryngoscopy examination. The % RGSA increase was calculated using [(RGSA-I - RGSA-E)/RGSA-E] × 100. Subjective laryngeal function was evaluated independently by two experienced surgeons blinded to treatment. RESULTS: The % RGSA increase within each treatment was greater for LS-B and LS-C than for LS-A (ALF-ISO: p = 0.03, PRO-ISO: p = < 0.001). There was no difference within each treatment from LS-B compared with LS-C. RGSA-I increased within each treatment from LS-A to both LS-B and LS-C (ALF-ISO: p = 0.002) and to LS-C (PRO-ISO: p = 0.006). Subjective laryngeal function scores improved from LS-A to LS-C. CONCLUSIONS AND CLINICAL RELEVANCE: Laryngeal function improved from postinduction examination following either 20 or 40 minutes of anesthesia with isoflurane via facemask. This study demonstrates that isoflurane may have a lesser effect on arytenoid abduction activity compared with more commonly used intravenous induction anesthetics (alfaxalone and propofol).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pregnanodionas / Propofol / Isoflurano Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pregnanodionas / Propofol / Isoflurano Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article