Inhibitor of apoptosis-stimulating p53 protein protects against inflammatory bowel disease in mice models by inhibiting the nuclear factor kappa B signaling.

Qian, Ke; Yuan, Lianwen; Wang, Shalong; Kuang, Yong; Jin, Qianqian; Long, Dongju; Jiang, Yuhong; Zhao, Hua; Liu, Kuijie; Yao, Hongliang

Qian, Ke; Yuan, Lianwen; Wang, Shalong; Kuang, Yong; Jin, Qianqian; Long, Dongju; Jiang, Yuhong; Zhao, Hua; Liu, Kuijie; Yao, Hongliang.

Afiliação

Qian K; Department of Gastroenterology, the Second Xiangya Hospital, Central South University, Changsha, China.
Yuan L; Department of Breast Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
Wang S; Department of Geriatric Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Kuang Y; Department of Geriatric Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Jin Q; Department of Gastroenterology, the Second Xiangya Hospital, Central South University, Changsha, China.
Long D; Department of Gastroenterology, the Second Xiangya Hospital, Central South University, Changsha, China.
Jiang Y; Department of Gastroenterology, the Second Xiangya Hospital, Central South University, Changsha, China.
Zhao H; Department of Gastroenterology, the Second Xiangya Hospital, Central South University, Changsha, China.
Liu K; Department of Gastroenterology, the Second Xiangya Hospital, Central South University, Changsha, China.
Yao H; Department of Gastroenterology, the Second Xiangya Hospital, Central South University, Changsha, China.

Clin Exp Immunol ; 205(2): 246-256, 2021 08.

Article em En | MEDLINE | ID: mdl-33942299

Assuntos

Anti-Inflamatórios/farmacologia; Apoptose/efeitos dos fármacos; Doenças Inflamatórias Intestinais/tratamento farmacológico; Doenças Inflamatórias Intestinais/metabolismo; NF-kappa B/metabolismo; Transdução de Sinais/efeitos dos fármacos; Proteína Supressora de Tumor p53/metabolismo; Adulto; Animais; Colite/tratamento farmacológico; Colite/metabolismo; Colo/efeitos dos fármacos; Colo/metabolismo; Citocinas/metabolismo; Sulfato de Dextrana/farmacologia; Modelos Animais de Doenças; Humanos; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Ácido Trinitrobenzenossulfônico/farmacologia; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis; NF-κB; dextran sulfate sodium (DSS)-induced colitis; inflammatory bowel disease (IBD); inhibitor of apoptosis stimulating p53 protein (iASPP)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Transdução de Sinais / NF-kappa B / Proteína Supressora de Tumor p53 / Apoptose / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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