Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation.
Stem Cells Transl Med
; 10(8): 1121-1128, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-33951336
ABSTRACT
Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea. Damage to the limbus due to chemical/physical injury, infections, or genetic disorders leads to limbal stem cell deficiency (LSCD) with partial or total vision loss. Presently, LSCD is treated by transplanting limbal stem cells from the healthy eye of the recipient, living-related, or cadaveric donors. This review discusses limbal-derived stem cells, the importance of extracellular matrix in stem cell niche maintenance, the historical perspective of treating LSCD, including related advantages and limitations, and our experience of limbal stem cell transplantation over the decades.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Limbo da Córnea
/
Epitélio Corneano
/
Doenças da Córnea
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article