Investigation of the relationships between sleep behaviors and risk of healthspan termination: a prospective cohort study based on 323,373 UK-Biobank participants.
Sleep Breath
; 26(1): 205-213, 2022 03.
Article
em En
| MEDLINE
| ID: mdl-33959859
ABSTRACT
OBJECTIVES:
To examine the associations between four sleep behaviors and the risk of healthspan termination.METHODS:
This study included 323,373 participants, free of terminated healthspan at baseline, from the UK-Biobank (UKB). We applied multivariable-adjusted Cox regression models to estimate the risk of terminated healthspan based on four sleep behaviors (insomnia/sleeplessness, napping, daytime sleepiness, and difficulty getting up from bed), which were self-reported and measured on Likert scales from "usually" to "never/rarely" experiences. In this study, healthspan was defined based on eight events that are strongly associated with longevity (congestive heart failure, myocardial infarction, chronic obstructive pulmonary disease, stroke, dementia, diabetes, cancer, and death).RESULTS:
Participants who reported the following unhealthy sleep behaviors had a significantly higher risk of terminated healthspan "usually experience sleeplessness/insomnia" (HR = 1.05, 95% CI 1.03-1.07; P < 0.001); "usually nap" (HR = 1.22, 95% CI 1.18-1.26; P < 0.01); "excessive daytime sleepiness" (HR = 1.25, 95% CI 1.19-1.32; P < 0.001); and "difficult getting up from bed" (HR = 1.08, 95% CI 1.05-1.10; P < 0.001). The corresponding population attributable risk percentage (PAR%) indicated that about 7% of healthspan termination in this cohort would have been eliminated if all participants had healthy sleep behaviors.CONCLUSION:
Participants who reported "usually experience sleeplessness/insomnia," "usually nap," "excessive daytime sleepiness," and "difficult getting up from bed" had increased risk of shortened healthspan. Therefore, adherence to healthy sleep behavior is significant for the extension of healthspan.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sono
/
Nível de Saúde
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Distúrbios do Sono por Sonolência Excessiva
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Distúrbios do Início e da Manutenção do Sono
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article