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Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1.
Pobric, Gorana; Taylor, Jason R; Ramalingam, Hemavathy M; Pye, Emily; Robinson, Louise; Vassallo, Grace; Jung, JeYoung; Bhandary, Misty; Szumanska-Ryt, Karolina; Theodosiou, Louise; Evans, D Gareth; Eelloo, Judith; Burkitt-Wright, Emma; Hulleman, Johan; Green, Jonathan; Garg, Shruti.
Afiliação
  • Pobric G; Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Room 3.310 Jean McFarlane Building, Oxford Road, Manchester, M13 9WL , UK.
  • Taylor JR; Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Room 3.310 Jean McFarlane Building, Oxford Road, Manchester, M13 9WL , UK.
  • Ramalingam HM; Child & Adolescent Mental Health Services, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Pye E; Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Room 3.310 Jean McFarlane Building, Oxford Road, Manchester, M13 9WL , UK.
  • Robinson L; Child & Adolescent Mental Health Services, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Vassallo G; Nationally Commissioned Complex NF1 Service, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Jung J; School of Psychology, Precision Imaging Beacon, University of Nottingham, Nottingham, UK.
  • Bhandary M; Child & Adolescent Mental Health Services, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Szumanska-Ryt K; Child & Adolescent Mental Health Services, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Theodosiou L; Child & Adolescent Mental Health Services, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Evans DG; Nationally Commissioned Complex NF1 Service, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Eelloo J; Faculty of Biology, Division of Evolution and Genomic Sciences, Manchester Centre for Genomic Medicine, Medicine and Health, North West Genomics Hub, University of Manchester, Manchester, UK.
  • Burkitt-Wright E; Nationally Commissioned Complex NF1 Service, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Hulleman J; Nationally Commissioned Complex NF1 Service, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Green J; Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Room 3.310 Jean McFarlane Building, Oxford Road, Manchester, M13 9WL , UK.
  • Garg S; Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Room 3.310 Jean McFarlane Building, Oxford Road, Manchester, M13 9WL , UK.
J Autism Dev Disord ; 52(4): 1478-1494, 2022 Apr.
Article em En | MEDLINE | ID: mdl-33963966
ABSTRACT
Neurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed poorer performance on measures of WM as compared to the control group. No group differences were observed in P300 amplitude at Pz, but P300 latency was shorter in the NF1 group. Topographic analyses of P300 amplitude showed group differences indicating neural processing differences in the NF1 group relative to controls, which possibly contribute to the cognitive deficits seen in this population.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neurofibromatose 1 / Transtorno do Espectro Autista Limite: Adolescent / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neurofibromatose 1 / Transtorno do Espectro Autista Limite: Adolescent / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article