Phthalates promote the invasion of hepatocellular carcinoma cells by enhancing the interaction between Pregnane X receptor and E26 transformation specific sequence 1.

Du, Yabing; Shi, Xiaoyi; Ma, Wang; Wen, Peihao; Yu, Pu; Wang, Xin; Fang, Pengli; Chen, Aixia; Gao, Zhiqiang; Cui, Kang

Du, Yabing; Shi, Xiaoyi; Ma, Wang; Wen, Peihao; Yu, Pu; Wang, Xin; Fang, Pengli; Chen, Aixia; Gao, Zhiqiang; Cui, Kang.

Afiliação

Du Y; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China. Electronic address: dyb_19861002@126.com.
Shi X; Department of Hepatobiliary and Pancreatic Surgery/Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities/ZhengZhou Key Laboratory of Hepatobiliary & Pancreatic Diseases and Organ Transplantation, The First Affiliated Hospital
Ma W; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China. Electronic address: doctormawang@126.com.
Wen P; Department of Hepatobiliary and Pancreatic Surgery, The First Aï¬liated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China. Electronic address: wenpeihao1982@163.com.
Yu P; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China. Electronic address: yupu1030@126.com.
Wang X; School of Environmental Science and Engineering, Chang'an University, Xi'an 710064, Shaanxi Province, PR China. Electronic address: wxgoal@163.com.
Fang P; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China. Electronic address: fangpl2014@outlook.com.
Chen A; Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China. Electronic address: aixiach@chd.edu.cn.
Gao Z; Department of Hepatobiliary and Pancreatic Surgery, The First Aï¬liated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China. Electronic address: drgaozhiqiang@163.com.
Cui K; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China. Electronic address: fcccuik@zzu.edu.cn.

Pharmacol Res ; 169: 105648, 2021 07.

Article em En | MEDLINE | ID: mdl-33965509

Assuntos

Carcinoma Hepatocelular/induzido quimicamente; Dibutilftalato/farmacologia; Disruptores Endócrinos/farmacologia; Neoplasias Hepáticas/induzido quimicamente; Ácidos Ftálicos/farmacologia; Receptor de Pregnano X/efeitos dos fármacos; Proteína Proto-Oncogênica c-ets-1/efeitos dos fármacos; Animais; Western Blotting; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; Células HEK293/efeitos dos fármacos; Humanos; Imunoprecipitação; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Camundongos; Camundongos Nus; Simulação de Acoplamento Molecular; Invasividade Neoplásica/patologia; Transplante de Neoplasias; Reação em Cadeia da Polimerase; Receptor de Pregnano X/metabolismo; Proteína Proto-Oncogênica c-ets-1/metabolismo

Palavras-chave

E26 transformation specific sequence 1; Endocrine-disrupting chemicals; Hepatocellular carcinoma; Phthalates; Pregnane X receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Ftálicos / Carcinoma Hepatocelular / Dibutilftalato / Proteína Proto-Oncogênica c-ets-1 / Disruptores Endócrinos / Receptor de Pregnano X / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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