Genetic features and efficacy of decitabine-based chemotherapy in elderly patients with acute myeloid leukemia.

Wang, Bianhong; Guan, Wei; Lv, Na; Li, Ting; Yu, Fan; Huang, Yuehua; Wang, Yanying; Li, Lihong; Yu, Li

Wang, Bianhong; Guan, Wei; Lv, Na; Li, Ting; Yu, Fan; Huang, Yuehua; Wang, Yanying; Li, Lihong; Yu, Li.

Afiliação

Wang B; Department of Hematology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People's Republic of China.
Guan W; Department of Hematology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Lv N; Department of Hematology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Li T; Department of Hematology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Yu F; Annoroad Gene Technology, Beijing, People's Republic of China.
Huang Y; Department of Hematology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People's Republic of China.
Wang Y; Department of Hematology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People's Republic of China.
Li L; Department of Hematology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People's Republic of China.
Yu L; Department of Hematology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People's Republic of China.

Hematology ; 26(1): 371-379, 2021 Dec.

Article em En | MEDLINE | ID: mdl-33971800

Assuntos

Decitabina/administração & dosagem; Leucemia Mieloide Aguda; Mutação; Proteínas de Neoplasias/genética; Adolescente; Adulto; Fatores Etários; Idoso; Idoso de 80 Anos ou mais; Intervalo Livre de Doença; Feminino; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/genética; Leucemia Mieloide Aguda/mortalidade; Masculino; Pessoa de Meia-Idade; Taxa de Sobrevida

Palavras-chave

Acute myeloid leukemia; clinical outcome; decitabine-based chemotherapy; elderly patients; epigenetic mutations; genetic features; mutational analysis; next generation sequencing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Decitabina / Mutação / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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