Single Cell Genomics for Tumor Heterogeneity.
Adv Exp Med Biol
; 1187: 205-214, 2021.
Article
em En
| MEDLINE
| ID: mdl-33983580
ABSTRACT
Single cell genomics became a universal and powerful tool to study cellular diversity at genomic levels in normal and disease conditions. Cancer is a disease of genomic instability which instigates clonal evolution and intra-tumoral heterogeneity. Cancer progression also accompanies gross alterations in the microenvironment, and the stromal or immune cell types comprising the tumor microenvironment can be explored by single cell genomics. So far, breast cancer has been analyzed by single cell genomic tools for the clonal evolution, inter- and intra-tumoral heterogeneity in molecular signatures, and tumor microenvironment. We will briefly go over those studies and discuss the potential application of single cell genomics for the diagnostics and management of cancer.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Genômica
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article