Dimeric Acylphloroglucinol Derivatives with New Skeletons from Leptospermum scoparium.
Chem Biodivers
; 18(6): e2100252, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33988294
ABSTRACT
Leptosparones A-F (1-6), six new dimeric acylphloroglucinol derivatives with unprecedented skeletons, were isolated from Leptospermum scoparium. Compounds 1-3 and 5-6 are phenylpropanoyl-phloroglucinol dimers, while 4 is a phenylpropanoylphloroglucinol-isovalerylphloroglucinol hybrid. Structurally, these compounds represent the first examples of dimeric phloroglucinols with unprecedented C(7')-C(8) linkage between the phloroglucinol core and the acyl side chain. Their structures were elucidated by comprehensive analyses of spectroscopic data, single crystal X-ray diffraction and chemical calculations. In addition, all compounds showed inhibitory effects against α-glucosidase with IC50 values ranging from 39.5 to 186.8â
µM.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Floroglucinol
/
Leptospermum
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Alfa-Glucosidases
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Inibidores de Glicosídeo Hidrolases
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article