Recent developments in <i>in vitro</i> and <i>in vivo</i> models for improved translation of preclinical pharmacokinetics and pharmacodynamics data.

Yadav, Jaydeep; El Hassani, Mehdi; Sodhi, Jasleen; Lauschke, Volker M; Hartman, Jessica H; Russell, Laura E

Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data.

Yadav, Jaydeep; El Hassani, Mehdi; Sodhi, Jasleen; Lauschke, Volker M; Hartman, Jessica H; Russell, Laura E.

Afiliação

Yadav J; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., Boston, MA, USA.
El Hassani M; Faculty of Pharmacy, Université de Montréal, Montréal, Canada.
Sodhi J; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, CA, USA.
Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Hartman JH; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Russell LE; Theravance Biopharma US, Inc., South San Francisco, CA, USA.

Drug Metab Rev ; 53(2): 207-233, 2021 05.

Article em En | MEDLINE | ID: mdl-33989099

Palavras-chave

Clearance prediction; in-vitro in-vivo extrapolation; in-vivo models; intrinsic clearance; zebrafish

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article