Pathological drivers of neurodegeneration in suspected non-Alzheimer's disease pathophysiology.
Alzheimers Res Ther
; 13(1): 100, 2021 05 14.
Article
em En
| MEDLINE
| ID: mdl-33990226
ABSTRACT
BACKGROUND:
Little is known about the heterogeneous etiology of suspected non-Alzheimer's pathophysiology (SNAP), a group of subjects with neurodegeneration in the absence of ß-amyloid. Using antemortem MRI and pathological data, we investigated the etiology of SNAP and the association of neurodegenerative pathologies with structural medial temporal lobe (MTL) measures in ß-amyloid-negative subjects.METHODS:
Subjects with antemortem MRI and autopsy data were selected from ADNI (n=63) and the University of Pennsylvania (n=156). Pathological diagnoses and semi-quantitative scores of MTL tau, neuritic plaques, α-synuclein, and TDP-43 pathology and MTL structural MRI measures from antemortem T1-weighted MRI scans were obtained. ß-amyloid status (A+/A-) was determined by CERAD score and neurodegeneration status (N+/N-) by hippocampal volume.RESULTS:
SNAP reflects a heterogeneous group of pathological diagnoses. In ADNI, SNAP (A-N+) had significantly more neuropathological diagnoses than A+N+. In the A- group, tau pathology was associated with hippocampal, entorhinal cortex, and Brodmann area 35 volume/thickness and TDP-43 pathology with hippocampal volume.CONCLUSION:
SNAP had a heterogeneous profile with more mixed pathologies than A+N+. Moreover, a role for TDP-43 and tau pathology in driving MTL neurodegeneration in the absence of ß-amyloid was supported.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Proteínas tau
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article