Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions.

Pennington, Luke F; Gasser, Pascal; Brigger, Daniel; Guntern, Pascal; Eggel, Alexander; Jardetzky, Theodore S

Pennington, Luke F; Gasser, Pascal; Brigger, Daniel; Guntern, Pascal; Eggel, Alexander; Jardetzky, Theodore S.

Afiliação

Pennington LF; Department of Structural Biology, Stanford University School of Medicine, Stanford, Calif; Program in Immunology, Stanford University School of Medicine, Stanford, Calif; Sean N. Parker Center for Allergy Research at Stanford University, Stanford, Calif.
Gasser P; Department of Rheumatology and Immunology, Bern University Hospital, Bern, Switzerland; Department of BioMedical Research, University of Bern, Bern, Switzerland.
Brigger D; Department of Rheumatology and Immunology, Bern University Hospital, Bern, Switzerland; Department of BioMedical Research, University of Bern, Bern, Switzerland.
Guntern P; Department of Rheumatology and Immunology, Bern University Hospital, Bern, Switzerland; Department of BioMedical Research, University of Bern, Bern, Switzerland.
Eggel A; Department of Rheumatology and Immunology, Bern University Hospital, Bern, Switzerland; Department of BioMedical Research, University of Bern, Bern, Switzerland. Electronic address: alexander.eggel@dbmr.unibe.ch.
Jardetzky TS; Department of Structural Biology, Stanford University School of Medicine, Stanford, Calif; Program in Immunology, Stanford University School of Medicine, Stanford, Calif; Sean N. Parker Center for Allergy Research at Stanford University, Stanford, Calif. Electronic address: tjardetzky@stanford.edu.

J Allergy Clin Immunol ; 148(4): 1049-1060, 2021 10.

Article em En | MEDLINE | ID: mdl-33991582

Assuntos

Anafilaxia/tratamento farmacológico; Imunoglobulina E/imunologia; Proteínas Recombinantes de Fusão; Alérgenos/imunologia; Anafilaxia/imunologia; Animais; Basófilos/efeitos dos fármacos; Basófilos/imunologia; Desenho de Fármacos; Humanos; Imunoglobulina E/química; Imunoglobulina E/genética; Camundongos Transgênicos; Estrutura Molecular; Ovalbumina/imunologia; Receptores de IgE/química; Receptores de IgE/genética; Receptores de IgE/imunologia; Proteínas Recombinantes de Fusão/química; Proteínas Recombinantes de Fusão/imunologia; Proteínas Recombinantes de Fusão/farmacologia; Proteínas Recombinantes de Fusão/uso terapêutico

Palavras-chave

Active desensitization; DARPins; Fc fusion; IgE; affinity maturation; allergies; anaphylaxis; disruptive IgE inhibitors; knobs in holes; yeast display

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Imunoglobulina E / Anafilaxia Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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