Genome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study.
Epigenomics
; 13(12): 939-951, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33993705
ABSTRACT
Aim:
Alcohol intake alters DNA methylation profiles and methylation might mediate the association between alcohol and disease, but limited number of positive CpG sites repeatedly replicated. Materials &methods:
In total, 57 monozygotic (MZ) twin pairs discordant for alcohol drinking from the Chinese National Twin Registry and 158 MZ and dizygotic twin pairs in the Swedish Adoption/Twin Study of Aging were evaluated. DNA methylation was detected using the Infinium HumanMethylation450 BeadChip.Results:
Among candidate CpG sites, cg07326074 was significantly correlated with drinking after adjusting for covariates in MZ twins in both datasets but not in the entire sample or dizygotic twins.Conclusion:
The hypermethylation of cg07326074, located in the tumor-promoting gene C16orf59, was associated with alcohol consumption.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Consumo de Bebidas Alcoólicas
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Biomarcadores
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Metilação de DNA
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Estudo de Associação Genômica Ampla
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Ácidos Nucleicos Livres
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article