One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study.
BMC Urol
; 21(1): 81, 2021 May 17.
Article
em En
| MEDLINE
| ID: mdl-34001094
ABSTRACT
BACKGROUND:
To examine one-year trajectories of urinary and sexual outcomes, and correlates of these trajectories, among prostate cancer patients treated by radical prostatectomy (RP).METHODS:
Study participants were recruited from 2011 to 2014 at two US institutions. Self-reported urinary and sexual outcomes were measured at baseline before surgery, and 5 weeks, 6 months and 12 months after surgery, using the modified Expanded Prostate Cancer Index Composite-50 (EPIC-50). Changes in EPIC-50 scores from baseline were categorized as improved (beyond baseline), maintained, or impaired (below baseline), using previously-reported minimum clinically important differences.RESULTS:
Of the 426 eligible participants who completed the baseline survey, 395 provided data on at least one EPIC-50 sub-scale at 5 weeks and 12 months, and were analyzed. Although all mean EPIC-50 scores declined markedly 5 weeks after surgery and then recovered to near (incontinence-related outcomes) or below (sexual outcomes) baseline levels by 12 months post-surgery, some men experienced improvement beyond their baseline levels on each sub-scale (3.3-51% depending on the sub-scale). Having benign prostatic hyperplasia (BPH) at baseline (prostate size ≥ 40 g; an International Prostate Symptom Index Score ≥ 8; or using BPH medications) was associated with post-surgical improvements in voiding dysfunction-related bother at 5 weeks (OR = 3.9, 95% CI 2.1-7.2) and 12 months (OR = 3.3, 95% CI 2.0-5.7); and in sexual bother at 5 weeks (OR = 5.7, 95% CI1.7-19.3) and 12 months (OR = 3.0, 95% CI 1.2-7.1).CONCLUSIONS:
Our findings provide additional support for considering baseline BPH symptoms when selecting the best therapy for early-stage prostate cancer.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Prostatectomia
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Neoplasias da Próstata
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article