Dual Inhibitors of Amyloid-ß and Tau Aggregation with Amyloid-ß Disaggregating Properties: Extended <i>In Cellulo</i>, <i>In Silico</i>, and Kinetic Studies of Multifunctional Anti-Alzheimer's Agents.

Pasieka, Anna; Panek, Dawid; Szalaj, Natalia; Espargaró, Alba; Wieckowska, Anna; Malawska, Barbara; Sabaté, Raimon; Bajda, Marek

Dual Inhibitors of Amyloid-ß and Tau Aggregation with Amyloid-ß Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer's Agents.

Pasieka, Anna; Panek, Dawid; Szalaj, Natalia; Espargaró, Alba; Wieckowska, Anna; Malawska, Barbara; Sabaté, Raimon; Bajda, Marek.

Afiliação

Pasieka A; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Panek D; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Szalaj N; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Espargaró A; Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, School of Pharmacy and Food Sciences, University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain.
Wieckowska A; Institute of Nanoscience and Nanotechnology (IN2UB), Av Joan XXIII, S/N, 08028 Barcelona, Spain.
Malawska B; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Sabaté R; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Bajda M; Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, School of Pharmacy and Food Sciences, University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain.

ACS Chem Neurosci ; 12(11): 2057-2068, 2021 06 02.

Article em En | MEDLINE | ID: mdl-34019757

Assuntos

Doença de Alzheimer; Peptídeos beta-Amiloides; Doença de Alzheimer/tratamento farmacológico; Inibidores da Colinesterase/farmacologia; Simulação por Computador; Desenho de Fármacos; Humanos; Cinética; Fragmentos de Peptídeos; Relação Estrutura-Atividade

Palavras-chave

Alzheimer's disease; aggregation inhibitors; molecular modeling; tau protein; ß-Amyloid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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