Innate immunity in lung transplantation.
J Heart Lung Transplant
; 40(7): 562-568, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-34020867
ABSTRACT
Innate immune pathways early after pulmonary transplantation have been shown to cause primary graft dysfunction (PGD) and also predispose to late graft failure. Recent studies in animal models have elucidated critical mechanisms governing such innate immune responses. Here, we discuss pathways of inflammatory cell death, triggers for sterile and infectious inflammation, and signaling cascades that mediate lung injury early after transplantation. These studies highlight potential avenues for lung-specific therapies early following lung transplantation to dampen innate immune responses and improve outcomes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Pulmão
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Disfunção Primária do Enxerto
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Rejeição de Enxerto
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Imunidade Inata
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article