Robotic in situ 3D bio-printing technology for repairing large segmental bone defects.
J Adv Res
; 30: 75-84, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-34026288
Introduction: The traditional clinical treatment of long segmental bone defects usually requires multiple operations and depends on donor availability. The 3D bio-printing technology constitutes a great potential therapeutic tool for such an injury. However, in situ 3D bio-printing remains a major challenge. Objectives: In this study, we report the repair of long segmental bone defects by in situ 3D bio-printing using a robotic manipulator 3D printer in a swine model. Methods: We systematically optimized bio-ink gelation under physiological conditions to achieve desirable mechanical properties suitable for bone regeneration, and a D-H kinematic model was used to improve printing accuracy to 0.5 mm. Results: These technical improvements allowed the repair of long segmental defects generated on the right tibia of pigs using 3D bio-printing within 12 min. The 3D bio-printing group showed improved treatment effects after 3 months. Conclusion: These findings indicated that robotic in situ 3D bio-printing is promising for direct clinical application.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osso e Ossos
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Substitutos Ósseos
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Engenharia Tecidual
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Bioimpressão
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Procedimentos Cirúrgicos Robóticos
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Impressão Tridimensional
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article