Late Stage Phosphotyrosine Mimetic Functionalization of Peptides Employing Metallaphotoredox Catalysis.
Org Lett
; 23(11): 4244-4249, 2021 06 04.
Article
em En
| MEDLINE
| ID: mdl-34029466
ABSTRACT
Access to phosphotyrosine (pTyr) mimetics requires multistep syntheses, and therefore late stage incorporation of these mimetics into peptides is not feasible. Here, we develop and employ metallaphotoredox catalysis using 4-halogenated phenylalanine to afford a variety of protected pTyr mimetics in one step. This methodology was shown to be tolerant of common protecting groups and applicable to the late stage pTyr mimetic modification of protected and unprotected peptides, and peptides of biological relevance.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Fenilalanina
/
Fosfotirosina
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article