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Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate.
Proks, Peter; Schewe, Marcus; Conrad, Linus J; Rao, Shanlin; Rathje, Kristin; Rödström, Karin E J; Carpenter, Elisabeth P; Baukrowitz, Thomas; Tucker, Stephen J.
Afiliação
  • Proks P; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.
  • Schewe M; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK.
  • Conrad LJ; Department of Physiology, University of Kiel, Kiel, Germany.
  • Rao S; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.
  • Rathje K; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK.
  • Rödström KEJ; Department of Biochemistry, University of Oxford, Oxford, UK.
  • Carpenter EP; Department of Physiology, University of Kiel, Kiel, Germany.
  • Baukrowitz T; Centre for Medicines Discovery, University of Oxford, UK.
  • Tucker SJ; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK.
J Gen Physiol ; 153(8)2021 08 02.
Article em En | MEDLINE | ID: mdl-34032848
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canais de Potássio de Domínios Poros em Tandem Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canais de Potássio de Domínios Poros em Tandem Idioma: En Ano de publicação: 2021 Tipo de documento: Article