Your browser doesn't support javascript.
loading
Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer.
Wang, Jieti; Li, Ruochen; Cao, Yifan; Gu, Yun; Fang, Hanji; Fei, Yuchao; Lv, Kunpeng; He, Xudong; Lin, Chao; Liu, Hao; Zhang, Heng; Li, He; He, Hongyong; Xu, Jiejie; Huang, Hua.
Afiliação
  • Wang J; Department of Gastric Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China.
  • Li R; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Cao Y; Department of Surgical Oncology, Minhang Branch, Shanghai Cancer Center, Fudan University, Shanghai, China.
  • Gu Y; Department of General Surgery, Suzhou Science&Technology Town Hospital, Nanjing Medical University, Suzhou, China.
  • Fang H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Fei Y; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Lv K; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • He X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • Lin C; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • Liu H; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • Zhang H; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • Li H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
  • He H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Xu J; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Huang H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Nat Commun ; 12(1): 3080, 2021 05 25.
Article em En | MEDLINE | ID: mdl-34035252
Studies that examined an association between CD8+T and prognosis in gastric cancer are inconsistent, and a distinct population of CXCR5+CD8+T associated with better overall survival has been reported among various malignancies. Here, we show that the abundance of intratumoral CXCR5+CD8+T cells is associated with better overall survival in patients with gastric cancer. Patients with TNM II + III gastric cancer with higher intratumoral CXCR5+CD8+T cell infiltration are more likely to benefit from adjuvant chemotherapy. Microsatellite-unstable and Epstein-Barr virus positive tumors are enriched with CXCR5+CD8+T cells. Gastric cancer infiltrating CXCR5+CD8+T cells represent a specific subtype of stem-like CD8+T with effector memory feature. Identification of the clinical significance and phenotype of gastric cancer infiltrating CXCR5+CD8+T provides a roadmap for patient stratification and trials of targeted therapies.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Linfócitos do Interstício Tumoral / Linfócitos T CD8-Positivos / Receptores CXCR5 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Linfócitos do Interstício Tumoral / Linfócitos T CD8-Positivos / Receptores CXCR5 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article