Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer's disease.

Zhang, Li; Qin, Zhaohong; Sharmin, Fariba; Lin, Wei; Ricke, Konrad M; Zasloff, Michael A; Stewart, Alexandre F R; Chen, Hsiao-Huei

Zhang, Li; Qin, Zhaohong; Sharmin, Fariba; Lin, Wei; Ricke, Konrad M; Zasloff, Michael A; Stewart, Alexandre F R; Chen, Hsiao-Huei.

Afiliação

Zhang L; Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON K1H8M5, Canada; University of Ottawa Brain and Mind Institute, Ottawa, ON K1H8M5, Canada.
Qin Z; Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON K1H8M5, Canada; University of Ottawa Brain and Mind Institute, Ottawa, ON K1H8M5, Canada.
Sharmin F; Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON K1H8M5, Canada; University of Ottawa Brain and Mind Institute, Ottawa, ON K1H8M5, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Lin W; Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON K1H8M5, Canada; University of Ottawa Brain and Mind Institute, Ottawa, ON K1H8M5, Canada.
Ricke KM; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada; University of Ottawa Heart Institute, Ottawa, ON K1Y4W7, Canada.
Zasloff MA; Georgetown University School of Medicine, MedStar Georgetown Transplant Institute, Washington, DC, 2007, USA.
Stewart AFR; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada; University of Ottawa Heart Institute, Ottawa, ON K1Y4W7, Canada. Electronic address: astewart@ottawaheart.ca.
Chen HH; Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON K1H8M5, Canada; University of Ottawa Brain and Mind Institute, Ottawa, ON K1H8M5, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada; Department of Medicine, University of Ottawa, Ottawa

Neurobiol Dis ; 156: 105402, 2021 08.

Article em En | MEDLINE | ID: mdl-34044147

Assuntos

Doença de Alzheimer/metabolismo; Plasticidade Neuronal/fisiologia; Proteína Tirosina Fosfatase não Receptora Tipo 1/metabolismo; Receptores de N-Metil-D-Aspartato/metabolismo; Receptores Pré-Sinápticos/metabolismo; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/genética; Animais; Colestanos/farmacologia; Colestanos/uso terapêutico; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Plasticidade Neuronal/efeitos dos fármacos; Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores; Proteína Tirosina Fosfatase não Receptora Tipo 1/genética; Receptores de N-Metil-D-Aspartato/genética; Receptores Pré-Sinápticos/genética; Espermina/análogos & derivados; Espermina/farmacologia; Espermina/uso terapêutico

Palavras-chave

Cognitive function; Hippocampus; Long-term potentiation; Presynaptic NMDA receptor; Short-term facilitation; Synaptic plasticity; Trodusquemine; Tyrosine phosphatase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de N-Metil-D-Aspartato / Receptores Pré-Sinápticos / Proteína Tirosina Fosfatase não Receptora Tipo 1 / Doença de Alzheimer / Plasticidade Neuronal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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