Regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions.
Org Biomol Chem
; 19(24): 5284-5288, 2021 06 28.
Article
em En
| MEDLINE
| ID: mdl-34047744
ABSTRACT
An efficient and straightforward metal-free regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide has been described. A series of indolizine-dithiocarbamate derivatives were easily accessed in moderate to good yields with a broad scope. In addition, imidazo[1,2-a]pyridines were also well tolerated to afford diverse imidazoheterocycle-dithiocarbamate products, which are expected to be utilized for drug discovery. Of note, the reaction could be readily scaled up, and shows its practical value in organic synthesis.
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MEDLINE
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En
Ano de publicação:
2021
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Article