CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2.
Biochem Biophys Res Commun
; 562: 146-153, 2021 07 12.
Article
em En
| MEDLINE
| ID: mdl-34052660
ABSTRACT
While molecular oxygen is essential for aerobic organisms, its utilization is inseparably connected with generation of oxidative insults. To cope with the detrimental aspects, cells evolved antioxidative defense systems, and insufficient management of the oxidative insults underlies the pathogenesis of a wide range of diseases. A battery of genes for this antioxidative defense are regulated by the transcription factors nuclear factor-erythroid 2-like 1 and 2 (NRF1 and NRF2). While the regulatory steps for the activation of NRFs have been investigated with particular emphasis on nuclear translocation and proteosomal degradation, unknown redundancy may exist considering the indispensable nature of these defense systems. Here we unraveled that C-terminal binding protein 2 (CtBP2), a transcriptional cofactor with redox-sensing capability, is an obligate partner of NRFs. CtBP2 forms transcriptional complexes with NRF1 and NRF2 that is required to promote the expression of antioxidant genes in response to oxidative insults. Our findings illustrate a basis for understanding the transcriptional regulation of antioxidative defense systems that may be exploited therapeutically.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases do Álcool
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Fator 1 Relacionado a NF-E2
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Fator 2 Relacionado a NF-E2
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Proteínas Correpressoras
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article