Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor.

Huestis, Malcolm P; Durk, Matthew R; Eigenbrot, Charles; Gibbons, Paul; Hunsaker, Thomas L; La, Hank; Leung, Dennis H; Liu, Wendy; Malek, Shiva; Merchant, Mark; Moffat, John G; Muli, Christine S; Orr, Christine J; Parr, Brendan T; Shanahan, Frances; Sneeringer, Christopher J; Wang, Weiru; Yen, Ivana; Yin, Jianping; Rudolph, Joachim; Siu, Michael

Huestis, Malcolm P; Durk, Matthew R; Eigenbrot, Charles; Gibbons, Paul; Hunsaker, Thomas L; La, Hank; Leung, Dennis H; Liu, Wendy; Malek, Shiva; Merchant, Mark; Moffat, John G; Muli, Christine S; Orr, Christine J; Parr, Brendan T; Shanahan, Frances; Sneeringer, Christopher J; Wang, Weiru; Yen, Ivana; Yin, Jianping; Rudolph, Joachim; Siu, Michael.

Afiliação

Huestis MP; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Durk MR; Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Eigenbrot C; Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Gibbons P; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Hunsaker TL; Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
La H; Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Leung DH; Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Liu W; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Malek S; Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Merchant M; Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Moffat JG; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Muli CS; Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Orr CJ; Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Parr BT; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Shanahan F; Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Sneeringer CJ; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Wang W; Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Yen I; Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Yin J; Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Rudolph J; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Siu M; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

ACS Med Chem Lett ; 12(5): 791-797, 2021 May 13.

Article em En | MEDLINE | ID: mdl-34055227

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article