Nuclear Respiratory Factor-1, a Novel SMAD4 Binding Protein, Represses TGF-ß/SMAD4 Signaling by Functioning as a Transcriptional Cofactor.

Rajasekaran, Nirmal; Song, Kyoung; Lee, Jin-Hee; Wei, Yun; Erkin, Özgür Cem; Lee, Hunseok; Shin, Young-Kee

Rajasekaran, Nirmal; Song, Kyoung; Lee, Jin-Hee; Wei, Yun; Erkin, Özgür Cem; Lee, Hunseok; Shin, Young-Kee.

Afiliação

Rajasekaran N; Laboratory of Molecular Pathology and Cancer Genomics, Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Song K; College of Pharmacy, Duksung Women's University, Seoul 01369, Korea.
Lee JH; Laboratory of Molecular Pathology and Cancer Genomics, Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Wei Y; Laboratory of Molecular Pathology and Cancer Genomics, Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Erkin ÖC; Department of Bioengineering, Faculty of Engineering, Adana Science and Technology, Adana 01250, Turkey.
Lee H; Laboratory of Molecular Pathology and Cancer Genomics, Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Shin YK; Laboratory of Molecular Pathology and Cancer Genomics, Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 08826, Korea.

Int J Mol Sci ; 22(11)2021 May 25.

Article em En | MEDLINE | ID: mdl-34070531

Assuntos

Inibidor de Quinase Dependente de Ciclina p15/metabolismo; Fator 1 Nuclear Respiratório/metabolismo; Transdução de Sinais/genética; Proteína Smad4/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Linhagem Celular Tumoral; Imunoprecipitação da Cromatina; Inibidor de Quinase Dependente de Ciclina p15/genética; Dimerização; Genes Supressores de Tumor; Humanos; Fator 1 Nuclear Respiratório/genética; Regiões Promotoras Genéticas; Ligação Proteica; Domínios Proteicos; Deleção de Sequência; Proteína Smad4/genética; Fator de Crescimento Transformador beta/farmacologia

Palavras-chave

NRF1; SMAD4; p15INK4b; transforming growth factor-ß; tumor suppression

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Fator de Crescimento Transformador beta / Proteína Smad4 / Inibidor de Quinase Dependente de Ciclina p15 / Fator 1 Nuclear Respiratório Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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