Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking.

Dumitrascuta, Maria; Bermudez, Marcel; Trovato, Olga; De Neve, Jolien; Ballet, Steven; Wolber, Gerhard; Spetea, Mariana

Dumitrascuta, Maria; Bermudez, Marcel; Trovato, Olga; De Neve, Jolien; Ballet, Steven; Wolber, Gerhard; Spetea, Mariana.

Afiliação

Dumitrascuta M; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Bermudez M; Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Str. 2+4, D-14195 Berlin, Germany.
Trovato O; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
De Neve J; Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.
Ballet S; Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.
Wolber G; Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Str. 2+4, D-14195 Berlin, Germany.
Spetea M; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.

Molecules ; 26(11)2021 05 28.

Article em En | MEDLINE | ID: mdl-34071603

Assuntos

Oligopeptídeos/genética; Peptídeos Opioides/química; Receptores Opioides mu/metabolismo; Dor Aguda/tratamento farmacológico; Analgésicos; Animais; Comportamento Animal; Células CHO; Cricetinae; Cricetulus; Cicloeptanos/farmacologia; Humanos; Hiperalgesia/tratamento farmacológico; Técnicas In Vitro; Inflamação/tratamento farmacológico; Masculino; Camundongos; Modelos Moleculares; Simulação de Acoplamento Molecular; Morfina/química; Morfina/farmacologia; Movimento/efeitos dos fármacos; Naloxona/farmacologia; Naltrexona/farmacologia; Manejo da Dor; Piperidinas/farmacologia; Nociceptina

Palavras-chave

inflammatory pain; molecular docking; multitarget ligands; nociceptin receptor; reward; side effects; µ-opioid receptor

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Receptores Opioides mu / Peptídeos Opioides Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google