A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression.

Noguchi, Takehisa; Hidaka, Kyosuke; Kobayashi, Satsuki; Matsumoto, Kenjiro; Yoshioka, Makoto; Hu, Xin; Maloney, David J; Yang, Shyh-Ming; Kato, Shinichi

Noguchi, Takehisa; Hidaka, Kyosuke; Kobayashi, Satsuki; Matsumoto, Kenjiro; Yoshioka, Makoto; Hu, Xin; Maloney, David J; Yang, Shyh-Ming; Kato, Shinichi.

Afiliação

Noguchi T; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Hidaka K; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Kobayashi S; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Matsumoto K; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Yoshioka M; ConverGene LLC, Cambridge, Maryland, USA.
Hu X; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.
Maloney DJ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.
Yang SM; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.
Kato S; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan.

Drug Dev Res ; 82(8): 1235-1246, 2021 12.

Article em En | MEDLINE | ID: mdl-34075610

Assuntos

Anti-Inflamatórios/farmacologia; Citocinas/antagonistas & inibidores; Ileíte/tratamento farmacológico; Indometacina/efeitos adversos; Proteínas/antagonistas & inibidores; Animais; Citocinas/biossíntese; Proteína p300 Associada a E1A/metabolismo; Ileíte/induzido quimicamente; Masculino; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/fisiologia; Peroxidase/metabolismo; Fosfoproteínas/metabolismo; Quinazolinas/farmacologia; Células RAW 264.7

Palavras-chave

CREB-binding protein (CBP) and p300; bromodomain and extra-terminal motif (BET) proteins; ileitis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas / Indometacina / Citocinas / Ileíte / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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