Preparation and Characterization of a Lutein Solid Dispersion to Improve Its Solubility and Stability.
AAPS PharmSciTech
; 22(5): 169, 2021 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-34080086
ABSTRACT
Lutein has been used as a dietary supplement for the treatment of eye diseases, especially age-related macular degeneration. For oral formulations, we investigated lutein stability in artificial set-ups mimicking different physiological conditions and found that lutein was degraded over time under acidic conditions. To enhance the stability of lutein upon oral intake, we developed enteric-coated lutein solid dispersions (SD) by applying a polymer, hydroxypropyl methylcellulose acetate succinate (HPMCAS-LF), through a solvent-controlled precipitation method. The SD were characterized in crystallinity, morphology, and drug entrapment. In the dissolution profile of lutein SD, a F80 formulation showed resistance toward the acidic environment under simulated gastric conditions while exhibiting a bursting drug release under simulated intestinal conditions. Our results highlight the potential use of HPMCAS-LF as an effective matrix to enhance lutein bioavailability during oral delivery and to provide novel insights into the eye-care supplement industry, with direct benefits for the health of patients.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Luteína
/
Metilcelulose
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article