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Impact of Multileaf Collimator Width on Dose Distribution in HyperArc Fractionated Stereotactic Irradiation for Multiple (-) Brain Metastases.
Ohira, Shingo; Ueda, Yoshihiro; Kanayama, Naoyuki; Isono, Masaru; Inui, Shoki; Komiyama, Riho; Washio, Hayate; Miyazaki, Masayoshi; Koizumi, Masahiko; Teshima, Teruki; Konishi, Koji.
Afiliação
  • Ohira S; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan; oohira-si@mc.pref.osaka.jp.
  • Ueda Y; Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Japan.
  • Kanayama N; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Isono M; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Inui S; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Komiyama R; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Washio H; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Miyazaki M; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Koizumi M; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Teshima T; Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Japan.
  • Konishi K; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
Anticancer Res ; 41(6): 3153-3159, 2021 Jun.
Article em En | MEDLINE | ID: mdl-34083310
ABSTRACT
BACKGROUND/

AIM:

To assess the impact of the width of multileaf collimator (MLC) on dose distributions on HyperArc fractionated stereotactic irradiation for multiple (5-10) brain metastases. PATIENTS AND

METHODS:

Twenty-one HyperArc (HA) plans were generated using the high definition (HD) MLC (2.5 mm) to deliver 30-35 Gy in 3-5 fractions (HA-HD). The HyperArc plans using Millennium (ML) MLC (5 mm) were retrospectively generated (HA-ML) using the same planning parameters with HA-HD. Dosimetric parameters between the planning target volume (PTV) and organs at risk (OARs) were compared.

RESULTS:

The conformity index was significantly higher (p<0.0001) in the HA-HD plans (0.95±0.04) than that in the HA-ML plans (0.92±0.06). The HA-HD provided significantly lower (p<0.0001) gradient index (5.6±2.5) than HA-ML (6.2±3.5). For the brainstem and retina (right), a statistically significant difference (p<0.05) was observed between the HA-HD (12.8±10.9 and 2.8±1.7 Gy, for brainstem and retina, respectively) and HA-ML (13.6±11.1 and 3.0±1.8 Gy) plans. For the brain tissue, the HA-HD plans statistically significantly reduced dosimetric parameters (p<0.0001) in all evaluated dose range (V6Gy-V28Gy).

CONCLUSION:

The narrower MLC provided significantly higher conformity, steeper dose gradient, and better normal tissue sparing.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Radiocirurgia / Metástase Neoplásica Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Radiocirurgia / Metástase Neoplásica Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article