Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability.
Exerc Sport Sci Rev
; 49(4): 267-273, 2021 10 01.
Article
em En
| MEDLINE
| ID: mdl-34091499
ABSTRACT
Breast Cancer gene 1 (BRCA1) is a large, multifunctional protein that regulates a variety of mechanisms in multiple different tissues. Our work established that Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nucleus. Here, we propose BRCA1 expression is critical for the maintenance of force production and mitochondrial respiration in skeletal muscle.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Músculo Esquelético
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article