The relationship between defects in DNA repair genes and autoinflammatory diseases.
Rheumatol Int
; 42(1): 1-13, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-34091703
ABSTRACT
Tissue inflammation and damage with the abnormal and overactivation of innate immune system results with the development of a hereditary disease group of autoinflammatory diseases. Multiple numbers of DNA damage develop with the continuous exposure to endogenous and exogenous genotoxic effects, and these damages are repaired through the DNA damage response governed by the genes involved in the DNA repair mechanisms, and proteins of these genes. Studies showed that DNA damage might trigger the innate immune response through nuclear DNA accumulation in the cytoplasm, and through chronic DNA damage response which signals itself and/or by micronucleus. The aim of the present review is to identify the effect of mutation that occurred in DNA repair genes on development of DNA damage response and autoinflammatory diseases.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reparo do DNA
/
Doenças Hereditárias Autoinflamatórias
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article