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Lichen planus - a clinical guide.
Solimani, Farzan; Forchhammer, Stephan; Schloegl, Alexandra; Ghoreschi, Kamran; Meier, Katharina.
Afiliação
  • Solimani F; Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Forchhammer S; Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, Germany.
  • Schloegl A; Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, Germany.
  • Ghoreschi K; Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Meier K; Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
J Dtsch Dermatol Ges ; 19(6): 864-882, 2021 06.
Article em En | MEDLINE | ID: mdl-34096678
Lichen planus (LP) is a chronic lichenoid inflammatory disorder of the skin, mucosa and of the appendages. LP is classically characterized by the presence of a rich infiltration of inflammatory T cells, which migrate in the upper part of the dermis, arranged in a band-like pattern. Different sub types of the disease have been so far described. Albeit LP is clinically well defined, the disease still represents a therapeutic enigma. Especially with regard to mucosal or scalp affecting LP types, which often present a recalcitrant and treatment unresponsive course, efficacious therapeutic options are still lacking. Thus, LP represents a disease with a high psychosocial burden. Yet, development in the deciphering of LP pathogenesis reveals possible new druggable targets, thus paving the way for future therapeutic options. In this clinical guide, we summarize the current clinical knowledge and therapeutic standards and discuss the future perspective for the management of LP.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Líquen Plano Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Líquen Plano Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article