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Gold(I)-Catalyzed Reactivity of Furan-ynes with N-Oxides: Synthesis of Substituted Dihydropyridinones and Pyranones.
Nejrotti, Stefano; Marra, Francesco; Priola, Emanuele; Maranzana, Andrea; Prandi, Cristina.
Afiliação
  • Nejrotti S; Dipartimento di Chimica, Università degli Studi di Torino, via Pietro Giuria 7, I-10125 Torino, Italy.
  • Marra F; Dipartimento di Chimica, Università degli Studi di Torino, via Pietro Giuria 7, I-10125 Torino, Italy.
  • Priola E; Dipartimento di Chimica, Università degli Studi di Torino, via Pietro Giuria 7, I-10125 Torino, Italy.
  • Maranzana A; Dipartimento di Chimica, Università degli Studi di Torino, via Pietro Giuria 7, I-10125 Torino, Italy.
  • Prandi C; Dipartimento di Chimica, Università degli Studi di Torino, via Pietro Giuria 7, I-10125 Torino, Italy.
J Org Chem ; 86(12): 8295-8307, 2021 06 18.
Article em En | MEDLINE | ID: mdl-34100288
The reactivity of "furan-ynes" in combination with pyridine and quinoline N-oxides in the presence of a Au(I) catalyst, has been studied, enabling the synthesis of three different heterocyclic scaffolds. Selective access to two out of the three possible products, a dihydropyridinone and a furan enone, has been achieved through the fine-tuning of the reaction conditions. The reactions proceed smoothly at room temperature and open-air, and were further extended to a broad substrate scope, thus affording functionalized dihydropyridinones and pyranones.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óxidos / Ouro Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óxidos / Ouro Idioma: En Ano de publicação: 2021 Tipo de documento: Article