Systematic review and meta-analysis of the association between paediatric obesity and telomere length.
Acta Paediatr
; 110(10): 2695-2703, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34101251
AIM: This systematic review and meta-analysis aimed to assess the association between paediatric obesity and telomere length. METHODS: We conducted a comprehensive literature search for original studies assessing the associations between obesity and telomere length in children. Fixed or random effects with inverse-variance meta-analysis were used to estimate the standardised mean difference (SMD) and its 95% confidence interval (95% CI) between overweight or obese and normal-weight children. Heterogeneity was assessed using the I2 statistic, and meta-regression analyses were used to evaluate the potential source of heterogeneity. Subgroup analysis was further conducted by sex. RESULTS: A total of 11 studies were included. The meta-analysis showed that children who were overweight or obese had shorter telomere length than normal-weight children (SMD: -0.85; 95% CI: -1.42 to -0.28; p < 0.01). However, significant heterogeneity was present (I2 = 97%; p < 0.01). Study design, methods used for measuring telomere length, tissue types, mean age, and percentage of boys were not the source of heterogeneity revealed by meta-regression analysis. The inverse trend was significant only in boys, but not in girls. CONCLUSION: There was a negative association between paediatric obesity and telomere length. Weight control in children might have beneficial effect on telomere length.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Obesidade Infantil
Tipo de estudo:
Risk_factors_studies
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Systematic_reviews
Limite:
Child
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article