A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma.
J Exp Clin Cancer Res
; 40(1): 189, 2021 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-34103089
ABSTRACT
Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway's contribution to the development and progression of neuroblastoma. This review compiles up-to-date evidence of this pathway's involvement in neuroblastoma. We discuss the RAS-MAPK pathway's general functioning, the clinical implications of its deregulation in neuroblastoma, and current promising therapeutics targeting proteins involved in signaling.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema de Sinalização das MAP Quinases
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Neuroblastoma
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article