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Current Perspectives on the Diagnosis and Management of Primary Urethral Cancer: A Systematic Review.
Farrell, M Ryan; Xu, Jonathan T; Vanni, Alex J.
Afiliação
  • Farrell MR; Center for Reconstructive Urologic Surgery, Lahey Hospital and Medical Center, Burlington, MA, USA.
  • Xu JT; Center for Reconstructive Urologic Surgery, Lahey Hospital and Medical Center, Burlington, MA, USA.
  • Vanni AJ; Center for Reconstructive Urologic Surgery, Lahey Hospital and Medical Center, Burlington, MA, USA.
Res Rep Urol ; 13: 325-334, 2021.
Article em En | MEDLINE | ID: mdl-34104638
ABSTRACT
Primary urethral cancer (PUC) is a rare but highly aggressive malignancy that causes malignant urethral obstruction. We conducted a literature review using PubMed to identify original research studies that assessed the diagnosis and management of primary urethral cancer. PUC affects men more than women, is more common in African Americans than Caucasians, and is associated with history of chronic inflammation and irritation of the urinary tract. Patients suspected of PUC should undergo a complete work-up including cystoscopy, magnetic resonance imaging, and biopsy. In men and women, surgical monotherapy ranging from organ-sparing to more radical reconstructive procedures has adequate survival rates for early stage PUC and has been shown to be similarly as effective as radiation monotherapy, while multimodal therapy has become the standard of treatment for advanced stage PUC. Salvage surgery or radiation therapy has been linked with increased survival rates. Nodal involvement at the time of diagnosis is a negative prognosticator and should be treated with multimodal therapy. Further prospective studies with greater sample sizes and standardized clinical trials would allow for greater consistency in evaluating the different treatment modalities for PUC.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Ano de publicação: 2021 Tipo de documento: Article