Au/Pt-Egg-in-Nest Nanomotor for Glucose-Powered Catalytic Motion and Enhanced Molecular Transport to Living Cells.
Angew Chem Int Ed Engl
; 60(32): 17579-17586, 2021 08 02.
Article
em En
| MEDLINE
| ID: mdl-34107153
ABSTRACT
Nanostructures converting chemical energy to mechanical work by using benign metabolic fuels, have huge implications in biomedical science. Here, we introduce Au/Pt-based Janus nanostructures, resembling to "egg-in-nest" morphology (Au/Pt-ENs), showing enhanced motion as a result of dual enzyme-relay-like catalytic cascade in physiological biomedia, and in turn showing molecular-laden transport to living cells. We developed dynamic-casting approach using silica yolk-shell nanoreactors first, to install a large Au-seed fixing the silica-yolk aside while providing the anisotropically confined concave hollow nanospace to grow curved Pt-dendritic networks. Owing to the intimately interfaced Au and Pt catalytic sites integrated in a unique anisotropic nest-like morphology, Au/Pt-ENs exhibited high diffusion rates and displacements as the result of glucose-converted oxygen concentration gradient. High diffusiophoresis in cell culture media increased the nanomotor-membrane interaction events, in turn facilitated the cell internalization. In addition, the porous network of Au/Pt-ENs facilitated the drug-molecule cargo loading and delivery to the living cells.
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Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
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Nanotecnologia
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Nanopartículas
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Glucose
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article