C=C Bond Oxidative Cleavage of BODIPY Photocages by Visible Light.
Chemistry
; 27(44): 11268-11272, 2021 Aug 05.
Article
em En
| MEDLINE
| ID: mdl-34114272
ABSTRACT
Photocages for protection and the controlled release of bioactive compounds have been widely investigated. However, the vast majority of these photocages employ the cleavage of single bonds and high-energy ultraviolet light. The construction of a photoactivation system that uses visible light to cleave unsaturated bonds still remains a challenge. Herein, we report a regioselective oxidative cleavage of C=C bonds from a boron-dipyrrolemethene (BODIPY)-based photocage by illumination at 630â
nm, resulting in a free aldehyde and a thiol fluorescent probe. This strategy was demonstrated in live HeLa cells, and the generated α-formyl-BODIPY allowed real-time monitoring of aldehyde release in the cells. In particular, it is shown that a mannose-functionalized photocage can target HepG2 cells.
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Base de dados:
MEDLINE
Assunto principal:
Boro
/
Compostos de Boro
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article