Tea tree oil extract causes mitochondrial superoxide production and apoptosis as an anticancer agent, promoting tumor infiltrating neutrophils cytotoxic for breast cancer to induce tumor regression.

Clark, Amanda M; Magawa, Chandi; Pliego-Zamora, Adriana; Low, Pauline; Reynolds, Max; Ralph, Stephen J

Clark, Amanda M; Magawa, Chandi; Pliego-Zamora, Adriana; Low, Pauline; Reynolds, Max; Ralph, Stephen J.

Afiliação

Clark AM; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Magawa C; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Pliego-Zamora A; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Low P; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Reynolds M; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia; Australian Botanical Bioscience Pty. Ltd., Australia.
Ralph SJ; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia. Electronic address: s.ralph@griffith.edu.au.

Biomed Pharmacother ; 140: 111790, 2021 Aug.

Article em En | MEDLINE | ID: mdl-34119930

Assuntos

Antineoplásicos/uso terapêutico; Neoplasias Mamárias Experimentais/tratamento farmacológico; Melaleuca; Óleo de Melaleuca/uso terapêutico; Animais; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Chlorocebus aethiops; Feminino; Humanos; Neoplasias Mamárias Experimentais/imunologia; Neoplasias Mamárias Experimentais/metabolismo; Neoplasias Mamárias Experimentais/patologia; Camundongos Transgênicos; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Neutrófilos/efeitos dos fármacos; Neutrófilos/imunologia; Extratos Vegetais; Espécies Reativas de Oxigênio/metabolismo; Superóxidos/metabolismo; Óleo de Melaleuca/farmacologia; Células Vero

Palavras-chave

Apoptosis; Breast cancer; Cytotoxicity; Melaleuca alternifolia concentrate; Tumor infiltrating neutrophils

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óleo de Melaleuca / Melaleuca / Neoplasias Mamárias Experimentais / Antineoplásicos Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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