4D Printing of Shape Memory Vascular Stent Based on ßCD-g-Polycaprolactone.
Macromol Rapid Commun
; 42(14): e2100176, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-34121258
ABSTRACT
The 4D-printing technology is applied to fabricate a shape memory peripheral stent with good biocompatibility, which sustains long-term drug release. The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of ß-cyclodextrin (ßCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL. Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and ßCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body. The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent. The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells. Due to the presence of ßCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release. This study provides a new strategy to solve the urgent need of small-diameter scaffolds to treat critical limb ischemia.
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Base de dados:
MEDLINE
Assunto principal:
Células Endoteliais
/
Beta-Ciclodextrinas
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article