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Analytical performance of the Xpert MTB/XDR® assay for tuberculosis and expanded resistance detection.
Georghiou, Sophia B; Penn-Nicholson, Adam; de Vos, Margaretha; Macé, Aurélien; Syrmis, Melanie W; Jacob, Kevin; Mape, Alyanna; Parmar, Heta; Cao, Yuan; Coulter, Chris; Ruhwald, Morten; Pandey, Sushil K; Schumacher, Samuel G; Denkinger, Claudia M.
Afiliação
  • Georghiou SB; FIND, Geneva, Switzerland.
  • Penn-Nicholson A; FIND, Geneva, Switzerland.
  • de Vos M; FIND, Geneva, Switzerland.
  • Macé A; FIND, Geneva, Switzerland.
  • Syrmis MW; Queensland Mycobacterium Reference Laboratory, Pathology Queensland, Queensland, Australia; The University of Queensland Centre for Clinical Research, University of Queensland, Queensland, Australia.
  • Jacob K; Queensland Mycobacterium Reference Laboratory, Pathology Queensland, Queensland, Australia.
  • Mape A; Queensland Mycobacterium Reference Laboratory, Pathology Queensland, Queensland, Australia.
  • Parmar H; New Jersey Medical School, Rutgers University, New Jersey, USA.
  • Cao Y; New Jersey Medical School, Rutgers University, New Jersey, USA.
  • Coulter C; Queensland Mycobacterium Reference Laboratory, Pathology Queensland, Queensland, Australia.
  • Ruhwald M; FIND, Geneva, Switzerland.
  • Pandey SK; Queensland Mycobacterium Reference Laboratory, Pathology Queensland, Queensland, Australia.
  • Schumacher SG; FIND, Geneva, Switzerland. Electronic address: samuel.schumacher@finddx.org.
  • Denkinger CM; FIND, Geneva, Switzerland; Division of Tropical Medicine, Center of Infectious Diseases, University Hospital of Heidelberg, Heidelberg, Germany.
Diagn Microbiol Infect Dis ; 101(1): 115397, 2021 Sep.
Article em En | MEDLINE | ID: mdl-34130215
ABSTRACT
In a manufacturer-independent laboratory validation study, the Xpert MTB/XDR® assay demonstrated equivalent limit of detection to Xpert MTB/RIF®, detected 100% of tested resistance mutations and showed some utility for resistance detection in strain mixtures. The Xpert MTB/XDR assay is a reliable, sensitive assay for tuberculosis and expanded resistance detection.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Técnicas de Diagnóstico Molecular / Farmacorresistência Bacteriana Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Técnicas de Diagnóstico Molecular / Farmacorresistência Bacteriana Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article