Advancing our understanding of HIV co-infections and neurological disease using the humanized mouse.
Retrovirology
; 18(1): 14, 2021 06 16.
Article
em En
| MEDLINE
| ID: mdl-34134725
ABSTRACT
Humanized mice have become an important workhorse model for HIV research. Advances that enabled development of a human immune system in immune deficient mouse strains have aided new basic research in HIV pathogenesis and immune dysfunction. The small animal features facilitate development of clinical interventions that are difficult to study in clinical cohorts, and avoid the high cost and regulatory burdens of using non-human primates. The model also overcomes the host restriction of HIV for human immune cells which limits discovery and translational research related to important co-infections of people living with HIV. In this review we emphasize recent advances in modeling bacterial and viral co-infections in the setting of HIV in humanized mice, especially neurological disease, and Mycobacterium tuberculosis and HIV co-infections. Applications of current and future co-infection models to address important clinical and research questions are further discussed.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Camundongos Transgênicos
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Infecções por HIV
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HIV-1
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Modelos Animais de Doenças
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Doenças do Sistema Nervoso
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article