Alveolar Macrophages Inherently Express Programmed Death-1 Ligand 1 for Optimal Protective Immunity and Tolerance.
J Immunol
; 207(1): 110-114, 2021 07 01.
Article
em En
| MEDLINE
| ID: mdl-34135059
ABSTRACT
Macrophages play a central role in lung physiology and pathology. In this study, we show in mice that alveolar macrophages (AMs), unlike other macrophage types (interstitial, peritoneal, and splenic macrophages), constitutively express programmed death-1 ligand 1 (PD-L1), thereby possessing a superior phagocytic ability and the capacity to repress CTLs by cis- and trans-interacting with CD80 and programmed death-1 (PD-1), respectively. This extraordinary ability of AMs assures optimal protective immunity and tolerance within the lung. These findings uncover a unique characteristic of AMs and an innate immune function of PD-L1 and CD80 and therefore help in the understanding of lung physiology, diseases, and PD-L1/PD-1-based immunotherapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Macrófagos Alveolares
/
Antígeno B7-H1
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article