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Humoral Response after SARS-CoV-2 mRNA Vaccination in a Cohort of Hemodialysis Patients and Kidney Transplant Recipients.
Danthu, Clément; Hantz, Sébastien; Dahlem, Arthur; Duval, Marion; Ba, Bacary; Guibbert, Manon; El Ouafi, Zhour; Ponsard, Séverine; Berrahal, Insaf; Achard, Jean-Michel; Bocquentin, Frédérique; Allot, Vincent; Rerolle, Jean-Philippe; Alain, Sophie; Touré, Fatouma.
Afiliação
  • Danthu C; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
  • Hantz S; UMR Institut National de la Santé et de la Recherche Médicale 1092, RESINFIT, Limoges, France.
  • Dahlem A; UMR Institut National de la Santé et de la Recherche Médicale 1092, RESINFIT, Limoges, France.
  • Duval M; Department of Virology, Hospital University of Limoges, Limoges, France.
  • Ba B; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
  • Guibbert M; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
  • El Ouafi Z; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
  • Ponsard S; Department of Virology, Hospital University of Limoges, Limoges, France.
  • Berrahal I; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
  • Achard JM; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
  • Bocquentin F; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
  • Allot V; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
  • Rerolle JP; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
  • Alain S; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
  • Touré F; Department of Nephrology, Dialysis and Transplantation, Hospital University of Limoges, Limoges, France.
J Am Soc Nephrol ; 32(9): 2153-2158, 2021 09.
Article em En | MEDLINE | ID: mdl-34135083
ABSTRACT

BACKGROUND:

Kidney transplant recipients and patients receiving hemodialysis are immunocompromised populations that are prioritized for COVID-19 vaccination but were excluded from clinical trials of SARS-CoV-2 mRNA vaccines. Antibody titers and rates of seroconversion after vaccination are lower among patients with CKD and those taking immunosuppressants compared with controls. Data are lacking regarding their humoral response to vaccination to prevent COVID-19.

METHODS:

This investigation of early serological response after COVID-19 vaccination with the Pfizer/BioNTech (BNT162b2) mRNA vaccine included 78 patients undergoing hemodialysis, 74 kidney transplant recipients, and seven healthy controls. We recorded data from the medical file for various clinical parameters, including response to hepatitis B vaccination, and measured antibody titers against SARS-CoV-2 at 0, 14, 28, 36, and 58 days after the first injection.

RESULTS:

In controls, we detected antibodies at a positive level (>13 arbitrary units per ml; AU/ml) at day 14 postinjection, which increased progressively to peak at day 36 (1082 AU/ml; interquartile range [IQR], 735.0-1662.0). Patients undergoing hemodialysis had lower titers that peaked at day 58 (276 AU/ml; IQR, 83.4-526.0). We detected a positive antibody level in only three transplant recipients at day 36. In patients on hemodialysis, those aged <75 years had a higher antibody response versus those aged >75 years, and serum albumin and Kt/V were positively correlated with serological response (P<0.04 and P<0.0, respectively); nonresponders to HBV vaccine had the lowest anti-SARS-CoV-2 antibody titers.

CONCLUSIONS:

Our results suggest that the postvaccination humoral response is strongly inhibited by immunosuppressant therapy in kidney transplant recipients, and is reduced by the uremic condition in patients undergoing hemodialysis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diálise Renal / Transplante de Rim / Vacinas contra COVID-19 / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diálise Renal / Transplante de Rim / Vacinas contra COVID-19 / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article