Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model.

Wang, Xian-Feng; Yang, Sheng-An; Gong, Shangyu; Chang, Chih-Hsuan; Portilla, Juan Martin; Chatterjee, Deeptiman; Irianto, Jerome; Bao, Hongcun; Huang, Yi-Chun; Deng, Wu-Min

Wang, Xian-Feng; Yang, Sheng-An; Gong, Shangyu; Chang, Chih-Hsuan; Portilla, Juan Martin; Chatterjee, Deeptiman; Irianto, Jerome; Bao, Hongcun; Huang, Yi-Chun; Deng, Wu-Min.

Afiliação

Wang XF; Department of Biochemistry and Molecular Biology, Tulane University Louisiana Center Research Center, New Orleans, LA 70112, USA.
Yang SA; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Gong S; Department of Biochemistry and Molecular Biology, Tulane University Louisiana Center Research Center, New Orleans, LA 70112, USA.
Chang CH; Department of Biochemistry and Molecular Biology, Tulane University Louisiana Center Research Center, New Orleans, LA 70112, USA.
Portilla JM; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Chatterjee D; Department of Biochemistry and Molecular Biology, Tulane University Louisiana Center Research Center, New Orleans, LA 70112, USA.
Irianto J; Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA.
Bao H; Department of Biochemistry and Molecular Biology, Tulane University Louisiana Center Research Center, New Orleans, LA 70112, USA.
Huang YC; Department of Biochemistry and Molecular Biology, Tulane University Louisiana Center Research Center, New Orleans, LA 70112, USA.
Deng WM; Department of Biochemistry and Molecular Biology, Tulane University Louisiana Center Research Center, New Orleans, LA 70112, USA; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. Electronic address: wdeng7@tulane.edu.

Dev Cell ; 56(13): 1976-1988.e4, 2021 07 12.

Article em En | MEDLINE | ID: mdl-34146466

Assuntos

Carcinogênese/genética; Instabilidade Genômica/genética; Neoplasias/genética; Poliploidia; Animais; Ciclo Celular/genética; Drosophila melanogaster/genética; Epistasia Genética/genética; Dosagem de Genes/genética; Heterogeneidade Genética; Humanos; Meiose/genética; Mitose/genética; Neoplasias/patologia; Ploidias; RNA-Seq; Receptores Notch/genética; Transdução de Sinais

Palavras-chave

Drosophila tumor model; aneuploidy; chromosomal instability (CIN); copy number variations (CNV); depolyploidization; ploidy reduction; polyaneuploidy; tumor evolution; tumor hotspot; tumor progression

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliploidia / Instabilidade Genômica / Carcinogênese / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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